Fig. 3: Inflammation induces iASPP expression in vivo and high iASPP mRNA associates with good prognosis of classical PC.
From: p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer
A Human pancreas iASPP staining. iASPP expression in normal pancreas (left), chronic pancreatitis (centre), and pancreatic cancer (right). Ductal metaplasia denoted by black arrows. Scale bar, 100 µm (inset scale bar, 40 µm). B iASPP histoscore in relation to human tissue histology; normal (n = 10), pancreatitis (n = 11), pancreatic cancer (PC) (n = 42) and metastasis (n = 6) from pancreatic primary tissue. Error bars represent mean ± SEM, and data were analysed by unpaired t-test. ** = p < 0.01, **** = p < 0.0001. C Kaplan-Meier analysis for overall survival plot in CPTAC-3 and TCGA cohorts with high and low iASPP (PPP1R13L) mRNA expression cut-offs defined using maxstat R package. D Kaplan-Meier analysis for overall survival plot in classical (consensus) PC samples in the CPTAC-3 and TCGA cohorts with high and low iASPP (PPP1R13L) mRNA expression cut-offs defined using maxstat R package.
