Fig. 6: Effects of the NRF2 axis on regulation of miR-34a/b/c by H2O2, curcumin, hypoxia and IL-6. | Cell Death & Differentiation

Fig. 6: Effects of the NRF2 axis on regulation of miR-34a/b/c by H2O2, curcumin, hypoxia and IL-6.

From: Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis

Fig. 6: Effects of the NRF2 axis on regulation of miR-34a/b/c by H2O2, curcumin, hypoxia and IL-6.The alternative text for this image may have been generated using AI.

A–C Expression of NQO1 (A), pri-miR-34a (B), and pri-miR-34b/c (C) after treatment with H202 and transfection with control or NRF2 siRNA for 24 hours. D, E Expression of pri-miR-34a (D) and pri-miR-34b/c (E) in p53-deficient HCT116 cells after the indicated transfections/treatments. F, G Expression of pri-miR-34a (F) and pri-miR-34b/c (G) in indicated cells after transfection with control or NRF2 siRNA and treatment with curcumin and/or IL-6 (200 ng/ml) for 48 hours. In (A)–(G) mean values ± SD are shown (n = 3)*P <  0.05, **P <  0.01, ***P <  0.001, ****P  <  0.0001.

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