Fig. 2: Point mutations of F-ATP synthase affecting its channel properties. | Cell Death & Differentiation

Fig. 2: Point mutations of F-ATP synthase affecting its channel properties.

From: Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions

Fig. 2

The figure reports mutations of F-ATP synthase that affect specific features of the mPTP, i.e., conductance [47, 58], Ca2+-dependence [98], inhibition by H+ [279], sensitivity to glyoxals [280], and oxidants [281]. For details the reader is referred to the original publications indicated on the picture. Approximate positions of the mutations are indicated by red dots. The structure of F-ATP synthase used in the background is taken from ref. [67].

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