Fig. 8: Clinical association analysis of selected genes and miR-34a/b/c-KO-derived gene signatures. | Cell Death & Differentiation

Fig. 8: Clinical association analysis of selected genes and miR-34a/b/c-KO-derived gene signatures.

From: CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c in HCT116 colorectal cancer cells: comprehensive characterization after exposure to 5-FU reveals EMT and autophagy as key processes regulated by miR-34

Fig. 8

A Scatter plots showing the correlations of the indicated miR-34a/b/c-KO-derived signatures scores with IC50 values of 5-FU in CRC cell lines. Two-sided Pearson correlation coefficient r and p values are indicated. B Scatter plots showing correlations between selected gene expressions in the TCGA-CRC patient cohort. Pearson correlation coefficient r and p values are indicated. C Associations between miR-34a/b/c-KO-derived signatures scores with CMS subtypes in the indicated CRC patient cohorts. D Cox regression model analysis of the associations between miR-34a/b/c-KO-derived signatures scores with overall survival in the indicated CRC patient cohorts.

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