Fig. 9: Model of hornerin-mediated mitotic catastrophe.
From: Hornerin mediates phosphorylation of the polo-box domain in Plk1 by Chk1 to induce death in mitosis
Upon mitotic entry with DNA damage, Aurora A phosphorylates Ser526 for normal mitotic progression but hornerin mediates additional phosphorylations by Chk1 at Ser529 and The539 in Plk1 to induce multipolar spindle and concomitant mitotic catastrophe. KD kinase domain.
