Fig. 6: FasL upregulation in the bronchoalveolar lavage fluid of COVID-19 patients.
From: Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality
Human BALF scRNAseq data for UMAP projection (a) and Violin plots (b) depicting Fasl mRNA expression in immune cell populations as indicated (NK cells, healthy n = 97; COVID-19 n = 984; T cells, healthy n = 1225; COVID-19 n = 6491; macrophages, healthy n = 18539; COVID-19 n = 30878). p values in Violin plots (B) were determined by Wilcoxon Rank Sum test. *p < 0.0332, **p < 0.0021, ***p < 0.0002, ****p < 0.0001. c Cytokine protein analysis of FasL in BALF of 24 COVID-19 ICU patients with serial sample collection during hospitalization (n = 109) and IAV patients (n = 28) and healthy donors (n = 36) quantified by Luminex Multiplex Assay. p values were determined by Mann-Whitney test. *p < 0.0332, **p < 0.0021, ***p < 0.0002, ****p < 0.0001. Values represent mean ± SEM. NK cells: Natural Killer cells. BALF bronchoalveolar lavage fluid.
