Fig. 4: Blocking RIPK1 cleavage does not further sensitise Ripk3D333A/D333A mice to cell death.
From: RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation
a Representative pictures of ~300 days old mice with indicated genotypes. Cell death of BMDMs (b) and MDFs (c) monitored by time-lapse imaging of propidium iodide (PI) staining over 16 h (b) or 18 h (c) upon receiving treatments as described in Figs. 2a and 3a. Data are represented as mean + SEM of N = 2–3 independent biological replicates per genotype. Graphs are representative of 3 independent experiments performed with 2-3 independent biological replicates each time.
