Fig. 8: Schematic overview of events that lead to myeloid differentiation attributed to Prtn3 deficiency.
From: Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation
In WT mice, the level of G-CSF-induced STAT3 in LSK cells is counterbalanced by the PRTN3-dependent ubiquitin-mediated degradation of STAT3. In prtn3 knockout (KO) mice, G-CSF-induced a sustained STAT3 phosphorylation and nuclear translocation that promotes robust expression of differentiation genes, including C/Ebpα and P27kpi1, that stimulates myeloid differentiation to promote an increased.
