Fig. 2: Differentially expressed genes in Nlrp3tm1Flv mice are predominantly located on chromosome 11. | Cell Death & Differentiation

Fig. 2: Differentially expressed genes in Nlrp3tm1Flv mice are predominantly located on chromosome 11.

From: Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv mice

Fig. 2

a Volcano plots of gene expression fold-change versus P value in RNAseq of Nlrp3tm1Flv Nlrp3+/+ and Nlrp3−/− BMDMs. Total number of differentially expressed (DE, adj. P < 0.05, Benjamini–Hochberg adjusted) genes, and individual DE genes, are shown in red. Left: comparison at baseline. Middle: comparison after 3 h of LPS (10 ng/ml) stimulation. Right: comparison after 24 h of LPS (10 ng/ml) stimulation. b Heatmap of log2 normalised counts of genes commonly differentially expressed (adj P < 0.05, Benjamini–Hochberg adjusted) in all three comparisons above. c Pie charts showing the number of differentially expressed (DE) genes (adj. P < 0.05) in BMDMs and GMPs between Nlrp3tm1Flv Nlrp3+/+ and Nlrp3−/− mice, and whether they are located on chromosome 11 (blue) or an alternative chromosome (grey).

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