Fig. 5: Methionine restriction promotes immune cell infiltration in bladder cancer and synergizes with immune checkpoint inhibitors. | Cell Death & Differentiation

Fig. 5: Methionine restriction promotes immune cell infiltration in bladder cancer and synergizes with immune checkpoint inhibitors.

From: Methionine-driven YTHDF1 expression facilitates bladder cancer progression by attenuating RIG-I-modulated immune responses and enhancing the eIF5B-PD-L1 axis

Fig. 5: Methionine restriction promotes immune cell infiltration in bladder cancer and synergizes with immune checkpoint inhibitors.

A Experimental workflow of single-cell sequencing. B Tumor growth curves of mice in each treatment group. C Differential expression of CD8+ T cell-associated molecules across different clusters. D UMAP plot of tumor-infiltrating T cell clusters. Proportions (E) and UMAP plot (F) of tumor-infiltrating T cell clusters across different treatment groups. G Density UMAP plot of tumor-infiltrating T cell clusters in different treatment groups. H, I Potential developmental trajectories of CD8+ T cell clusters in the tumor microenvironment across different clusters. J Expression levels of Lag3, Havcr2, Id2, Sell, Tcf7, Prf1, and GzmB in CD8+ T cell clusters indicated on the UMAP plot. K Enriched pathways comparing MRD group to CD group. L Enriched pathways comparing MRD + αPD-L1 group to CD group. ***P < 0.001. CD complete diet, MRD methionine restricted diet.

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