Fig. 6: Deletion of YTHDF1 promotes immune cell infiltration in bladder cancer and synergizes with immune checkpoint inhibitors. | Cell Death & Differentiation

Fig. 6: Deletion of YTHDF1 promotes immune cell infiltration in bladder cancer and synergizes with immune checkpoint inhibitors.

From: Methionine-driven YTHDF1 expression facilitates bladder cancer progression by attenuating RIG-I-modulated immune responses and enhancing the eIF5B-PD-L1 axis

Fig. 6: Deletion of YTHDF1 promotes immune cell infiltration in bladder cancer and synergizes with immune checkpoint inhibitors.

A Diagram of the experimental workflow. Tumor growth curves (B), images of tumors (C), and tumor weights (D) for each treatment group. E Bar graphs and representative flow cytometry plots displaying the proportions of tumor-infiltrating CD4+ and CD8+ T cells per gram of tumor tissue in each treatment group. F Flow cytometry plots and bar graphs illustrating the proportions of CD8+ T cells producing IFN-γ and TNF-α in each treatment group. G Bar graphs and histograms showing the mean fluorescence intensity of CD44 and CD62L in CD8+ T cells across each treatment group. ns, P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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