Fig. 1: TT eradicates TNBC in young and adult mice. | Cell Death & Differentiation

Fig. 1: TT eradicates TNBC in young and adult mice.

From: Age-dependent differences in breast tumor microenvironment: challenges and opportunities for efficacy studies in preclinical models

Fig. 1

A In vivo live imaging of 4T1 tumors in adult (left side) and young (right side) mice treated either with vehicle or with TT. Images were taken at various time points, as indicated on the right. The luminescence/radiance bar on the left illustrates the intensity, with red corresponding to higher and blue the lowest luminescence. B Comparison of tumor growth in untreated and TT-treated young vs. adult mice (4T1 model; n = 10 per experimental group; ****: p-value < 0.0001, Student’s t-test). C Endpoint comparison reveals no differences in treated tumors, but a significant disparity in untreated tumors (with adult mice exhibiting larger tumors; **: p-value < 0.01, Student’s t-test). D Bar plot showing the average reduction in tumor mass upon TT for young and adult recipient mice.

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