Fig. 3: DPEP2 deficiency enhances inflammatory response of macrophages in vivo.
From: The Trim32-DPEP2 axis is an inflammatory switch in macrophages during intestinal inflammation
The DAI score (A) and colon length (B) of IBD models using macrophage-specific DPEP2-KO or WT mice at the indicated time points. n = 5 per group. The serum (C) or colonic (D) concentration of inflammatory cytokines in the IBD models using macrophage-specific DPEP2-KO or WT mice. n = 5 per group. The colonic concentration of inflammatory cytokines (E) and DAI score (F) in the HAEC-like models using macrophage-specific DPEP2-KO or WT mice. n = 5 per group. The colonic (G) concentration of inflammatory cytokines and DAI score (H) in the GVHD models using macrophage-specific DPEP2-KO or WT BM cells (C57BL/6) transplanted into irradiated BALB/c mice. n = 5 per group. I Kaplan-Meier survival curve showed that macrophage-specific Dpep2-deficiency significantly shortened overall survival of the GVHD mice. n = 15 per group. J–L Macrophage-specific Dpep2-deficiency induced higher serum concentration of inflammatory cytokines, higher ROS production (J, K, n = 10 per group), and shortened overall survival (K, n = 15 per group) of LPS-induced model of sepsis. All data are expressed as mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001.
