Fig. 2: KAT2A-dependent CRC cell lines express differentiation-associated genes. | Cell Death & Differentiation

Fig. 2: KAT2A-dependent CRC cell lines express differentiation-associated genes.

From: The histone modifier KAT2A presents a selective target in a subset of well-differentiated microsatellite-stable colorectal cancers

Fig. 2

a Volcano plot analysis of differentially expressed genes between KAT2A independent (green) and dependent (blue) CRC cell lines. Strongest hits are highlighted. b, c Gene set enrichment analysis (GSEA) indicating positive enrichment for gene signatures related to mature enterocytes in KAT2A-dependent CRC cell lines. d Differential expression of colon differentiation marker genes DDX60, EDN1, HPGD, IRF7, KRT23, and KRT20 between the KAT2A independent (green) and dependent (blue) groups. *p < 0.05; **p < 0.01, two-tailed Student’s t-test. e Correlation of relative gene expression of indicated differentiation markers (y-axis) and KAT2A dependency scores (x-axis) in all CRC cell lines. The Pearson correlation coefficients r and the p-values are shown.

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