Fig. 1: CD95 self-aggregation. | Cell Death & Differentiation

Fig. 1: CD95 self-aggregation.

From: CD95/Fas stoichiometry in future precision medicine

Fig. 1: CD95 self-aggregation.The alternative text for this image may have been generated using AI.

A Representation of CD95 with in the right, the amino acid numbers (numbering starts from methionine). The MMP7 cleavage site in the N-terminal region of CD95 is indicated [30]. B Left panel. Solvent accessible surface corresponds to structured domains CRD1, CRD2, and CRD3. The linker and part of the TM domain are shown in cartoons. The flexible sequence corresponds to amino acid residues 17 to 55 and is depicted schematically. In pink, the sequence 17-66, corresponding to mutants Del2 and Del3 [25], spanning the flexible sequence and part of the structured CRD1. The rest of the CRD1 is shaded in green. Right panel. Cartoon representation of the CRD1 of CD95 with intra-chain disulfide bonds. In pink, the residues 55-66 that are part of the predicted PLAD. In green, the rest of the CRD1.

Back to article page