Fig. 5: CS kidneys have increased expression of toxicity markers.
From: Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesis
A mRNA expression heatmap of the kidney injury markers (fold change ≥1.5-fold) in CS mice compared to WT mice. B qPCR was performed with the purified RNA from CS mice kidneys for kidney injury markers (Lcn2, Havcr1, and Timp1). Actin normalized expression values are shown. C Havcr1 immunohistochemistry (IHC) was performed with CS kidney tissue sections. A representative IHC image is shown (top), with quantitative analysis (bottom). Scale bar, 20 μm. Data are presented as mean ± SD (n ≥ 3). An unpaired t test was used for comparing CS with WT. A two-way ANOVA Sidak test was used for male vs female comparisons. p values indicated (Blue bar, WT; Red bar, HO CSA/CSB).
