Fig. 9: Mechanistic diagram. | Cell Death & Differentiation

Fig. 9: Mechanistic diagram.

From: Fatty acid synthesis promotes mtDNA release via ETS1-mediated oligomerization of VDAC1 facilitating endothelial dysfunction in sepsis-induced lung injury

Fig. 9

In sepsis, overwhelmed synthesis of fatty acids promotes ETS1 expression which limited the ubiquitination of VDAC1 and promoted its oligomerization. VDAC1 oligomerization facilitates the release mtDNA into the cytosol to activate cGAS-STING signaling, leading to endothelial dysfunction in sepsis-induced lung injury.

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