Fig. 7: Supplementation of GLUL can alleviate bone loss in SOP model mice. | Cell Death & Differentiation

Fig. 7: Supplementation of GLUL can alleviate bone loss in SOP model mice.

From: GLUL mediates FOXO3 O-GlcNAcylation to regulate the osteogenic differentiation of BMSCs and senile osteoporosis

Fig. 7

A Schematic diagram of in vivo experiment. B Representative micro-CT images of trabecular bone from the femoral metaphysis of mice(n = 4). C Quantitative analysis of BV/TV, Tb.Th, Tb.N and Tb.Sp. D ELISA detection results of serum P1NP levels in each group of mice (n = 4). E Immunohistochemical staining of osteogenesis-related genes in mice femur sections. (n = 3). F Calcein double-label staining image and quantitative analysis of the MAR and BFR/BS in each group of mice (n = 3). G Analysis of Osteoblast Density (N.O/BS) and Osteoblast Surface Area (O.S/BS) Data. H Representative images of ARS and ALP staining of BMSCs from mice of each group. I Quantitative analysis of ARS and ALP staining. J Representative images of VON KOSSA staining (n = 3). K Western blot analysis of the expression of osteogenesis-related genes in BMSCs from mice of each group. L Quantitative data analysis of Western blot results. **P < 0.01 vs. other groups; *P < 0.05 vs. other groups.

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