Table 2 Schematic summary for each biomarker-based cluster.
Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 | Cluster 5 | |
|---|---|---|---|---|---|
Hallmark | Other | Ferroptosis ++ Pyroptosis + Sepsis ++ | Sepsis + | Ferroptosis ++ Pyroptosis ++ Sepsis ++ AKI + | Ferroptosis + Sepsis + |
Biomarker profile | Low IL-6, IL-1ß, IL-18, IL-1ɑ, IL-1Ra, GDF15, MDA, Fec, urinary and serum CHI3L1. | High IL-6, TNF, IL-18, IL-10, IL-1Ra, GDF15, MDA, Fec, urinary and serum CHI3L1; low IL-1ɑ and IL-1ß. | High IL-6, GDF15, urinary and serum CHI3L1; low IL-6, IL-1ß, TNF, IL-18, IL-10, IL-1ɑ, IL-1Ra, MDA, and Fec. | High IL-6, IL-1ß, TNF, IL-18, IL-10, IL-1ɑ, IL-1Ra, GDF15, Fec. | High GDF15, MDA, and serum CHI3L1. |
Subject per cluster | n = 56 | n = 30 | n = 39 | n = 35 | n = 7 |
30-day mortality | 16% | 30% | 15% | 34% | 43% |
Max SOFAd1-d7 (median (IQR)) | 8 (4) | 11 (3) | 8 (5) | 11 (4) | 11 (3) |
Sepsis without shockd1-d7 | 43% | 33% | 54% | 37% | 71% |
Septic shockd1-d7 | 16% | 33% | 15% | 34% | 14% |
AKId1-d7 | 28% | 53% | 28% | 66% | 43% |
