Fig. 4: p300 is a crucial nuclear mediator of lactate signaling that regulates the polarization of M2. | Cell Death & Differentiation

Fig. 4: p300 is a crucial nuclear mediator of lactate signaling that regulates the polarization of M2.

From: Intestinal metabolite TMAO promotes CKD progression by stimulating macrophage M2 polarization through histone H4 lysine 12 lactylation

Fig. 4: p300 is a crucial nuclear mediator of lactate signaling that regulates the polarization of M2.The alternative text for this image may have been generated using AI.

A iNOS, IL-12, IL-6, IL-1β, and TNF-α mRNA expression in BMDM transfected with siNC, BMDM transfected with siNC and treated with 10 mM lactate for 48 h, BMDM transfected with siRNA-p300 and treated with 10 mM lactate for 48 h. B Arg-1, IL-10, YM-1, MR, Fizz1, and TGFβ1 mRNA expression in BMDM transfected with siNC, BMDM transfected with siNC and treated with 10 mM lactate for 48 h, BMDM transfected with siRNA-p300 and treated with 10 mM lactate for 48 h. C Flow cytometry plots and quantification of MHCII+ macrophage(M1) and CD206+ macrophage(M2) in BMDM transfected with siNC, BMDM transfected with siNC and treated with 10 mM lactate for 48 h, BMDM transfected with siRNA-p300 and treated with 10 mM lactate for 48 h.

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