Fig. 7: Serum TMAO level were up-regulated and positively associated with renal fibrosis and renal M2 polarization. | Cell Death & Differentiation

Fig. 7: Serum TMAO level were up-regulated and positively associated with renal fibrosis and renal M2 polarization.

From: Intestinal metabolite TMAO promotes CKD progression by stimulating macrophage M2 polarization through histone H4 lysine 12 lactylation

Fig. 7: Serum TMAO level were up-regulated and positively associated with renal fibrosis and renal M2 polarization.The alternative text for this image may have been generated using AI.

A 30 CKD patients mean serum TMAO level is statistically higher compared to 12 control(6 renal tumor relatively normal resected tissue and 6 healthy renal tissue), **p < 0.01. B–D CKD renal tissue α-SMA, Collegen I immunohistochemistry images (x50) and fibrotic area% (Masson staining) compared to control (renal tumor resected relatively normal tissue), **p < 0.01. E Immunofluorescence images(x50) on 6 CKD and 6 Con(renal resected) CD80(M1) and CD163(M2), *p < 0.05.

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