Fig. 2: BOK-deletion results in decreased proliferation in a p53 dependent manner. | Cell Death & Differentiation

Fig. 2: BOK-deletion results in decreased proliferation in a p53 dependent manner.

From: Loss of BOK increases vulnerability of p53 deficient non-small cell lung cancer cells to ATR inhibition through its role in uridine metabolism

Fig. 2: BOK-deletion results in decreased proliferation in a p53 dependent manner.

Viable cell numbers were measured over a period of four days using the PrestoBlue metabolic assay comparing BOK-proficient vs. BOK deficient cells. A A549 cells with a functional p53, N = 4. B p53-deficient A549 cells, N = 4. C A549 cells were left to grow for a period of 72 h, with or without supplementation with 100 µM CMP and 1 mM UMP. D KRAS-MYC NSCLC cells with a functional p53, N = 4. E KRAS-MYC NSCLC cells with a mutated p53, N = 4. F KRAS-MYC NSCLC cells were left to grow for a period of 72 h, with or without supplementation with 100 µM CMP and 1 mM UMP. Statistical analysis was performed by two-way ANOVA, followed by pairwise T-tests Bonferroni-adjusted (C, F) or by T-tests (A, B, D, E). *: p ≤ 0.05; **: p ≤ 0.01; ***: p ≤ 0.001; ****: p ≤ 0.0001.

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