Fig. 3: IB + NPCs induce neuroinflammatory and UPR related genes. | Cell Death & Differentiation

Fig. 3: IB + NPCs induce neuroinflammatory and UPR related genes.

From: ATF3-dependent formation of inclusion bodies in polyQ-expressing human iPSC-derived neurons confers cellular protection

Fig. 3: IB + NPCs induce neuroinflammatory and UPR related genes.The alternative text for this image may have been generated using AI.

A Left: A typical flow cytogram demonstrating IB- (bottom rectangle) and IB+ (top rectangle) cells. Right: Images representing IB− (left) and IB+ (right) NPCs. Scale bars = 200 µm. B Volcano plot of IB+/− 105Q-NPCs RNA-seq data. Blue and pink represent down- and up-regulated in IB+ NPCs, respectively. C Heatmap presenting the significantly altered DEGs between the three reproducible biological replicates of IB+/− 105Q-NPCs. D Gene Ontology (GO) analysis of pathways enriched in the up-regulated genes between IB+ and IB- 105Q-NPCs. E Volcano plot of IB+/− 180-NPCs RNA-seq data. Blue and pink represent down- and up-regulated genes in the IB+ NPCs, respectively. F Heatmap presenting the significantly altered DEGs between the three reproducible biological replicates of IB+/− 180Q-NPCs. G Gene Ontology (GO) analysis of pathways enriched in the up-regulated genes between IB+ and IB- 180Q-NPCs.

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