Fig. 5: ATF3 constitutively activates genes involved in UPR. | Cell Death & Differentiation

Fig. 5: ATF3 constitutively activates genes involved in UPR.

From: ATF3-dependent formation of inclusion bodies in polyQ-expressing human iPSC-derived neurons confers cellular protection

Fig. 5: ATF3 constitutively activates genes involved in UPR.The alternative text for this image may have been generated using AI.

A ChIP-seq metagene profile and heatmap of ATF3 ± 3 kb around the TSS in ATF3+/+ and ATF3−/− NPCs. B Representative genome browser views of ATF3 ChIP-seq data around MAFF and STK40 TSS for both ATF3+/+ and ATF3−/− NPCs. C Genome Browser tracks of ATF3 binding profile to itself. In panels (B) and (C), green and red tracks show ATF3 ChIP-seq in ATF3−/− and ATF3+/+ NPCs, respectively. Gene annotations are shown at the bottom (blue). Representative genome browser views of ATF3 ChIP-seq data in IB+ (blue), IB- (magenta), ATF3+/+ (red), and ATF3−/− (green) 105Q-NPCs around the genomic regions of UPR-related genes XBP1 (D), HSPA5 (E), HERPUD1 (F) and PPP2R5B (G). Gene annotation (blue) is at the bottom.

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