Table 6 Approved drugs used in human cardiovascular and neurodegenerative diseases, type 2 diabetes, ALD and NAFLD that regulate cell death in various tissues based on in vivo mouse studies.
Diseases in which drugs: control cell death, according to in vivo studies in mice | Diseases in which drugs: are approved for human use | |||
|---|---|---|---|---|
Cardiovascular diseases | Neurodegenerative diseases | T2D | ALD/NAFLD | |
Cardiovascular diseases | Ezetimibe A [317] Ticagrelor P [318] Inclisiran P [319] Colchicine P [320] Atorvastatin P [321] | combination of Benidipine and Edaravone A [324] | Metformin N [325] P [326] Pioglitazone t P [327] Dapagliflozin F [328] | - |
Neurodegenerative diseases | Rasagiline and Selegiline A [329] Edaravone A [330] | Dapagliflozin A [335] Sitagliptin A [336] Pioglitazone P [337] Thiazolidinediones F [338] | - | |
T2D | Sacubitril/valsartan A [339] | SGLT2 inhibitor with Linagliptin A [340] Linagliptin N [341] Empagliflozin P [342] | - | |
ALD/NAFLD | Pentoxifylline and Kaempferol A [343] | Geniposide A [344] | Empagliflozin A [345] Tirzepatide A [346] | - |
