Table 1 List of 10 mutually deregulated pathways between the parental and TAMR cell lines was revealed by metabolomic analysis.

From: Invasive lobular carcinoma: integrated multi-omics analysis reveals silencing of Argininosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistance

Pathway name

−log(p)

Impact

Cell pair

Alanine, aspartate and glutamate metabolism

7.57

0.47

SUM44

 

6.24

0.47

MB134

Arginine biosynthesis

4.33

0.37

SUM44

 

3.88

0.37

MB134

Lysine degradation

4.30

0.28

SUM44

 

3.92

0.28

MB134

Arachidonic acid metabolism

2.95

0.31

SUM44

 

2.48

0.31

MB134

D-Glutamine and D-glutamate metabolism

6.02

0.50

SUM44

 

4.93

0.50

MB134

Riboflavin metabolism

2.66

0.50

SUM44

 

3.88

0.50

MB134

Glycine, serine, and threonine metabolism

3.66

0.22

SUM44

 

2.02

0.22

MB134

Purine metabolism

4.04

0.28

SUM44

 

5.16

0.28

MB134

Arginine and proline metabolism

4.78

0.33

SUM44

 

3.23

0.33

MB134

Tyrosine metabolism

3.64

0.36

SUM44

 

3.68

0.36

MB134