Fig. 1: ULBP2 is overexpressed in GC and correlated with collagen deposition.
From: ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation
A The t-Distributed stochastic neighbour embedding (t-SNE) plot showing clustering information from GSE163558 and GSE206785. B Venn diagram showing the overlap between mRNA microarray, GSE163558 and GSE206785, upregulated genes associated with ECM, and Immunology Database and Analysis Portal (ImmPort) database. C Gene Ontology (GO) analysis showing enriched pathway terms for genes in GSE163558 and GSE206785. D ULBP2 expression in fibroblasts revealed a correlation with collagen biosynthesis, collagen fibril organisation, ECM-receptor interaction, and TGF-β signalling. E ULBP2 mRNA expression of GC and corresponding adjacent normal tissues analyzed by mRNA microarrays (n = 16). F Immunoblotting of ULBP2 in the tumors and corresponding adjacent normal tissues from GC patients (n = 6). G Quantification of ULBP2 expression by immunohistochemistry (IHC) in human tissue microarrays (TMAs) from 62 gastric patients. H Kaplan–Meier survival analysis of overall survival (OS). I Representative images of gastric tissues with high ULBP2 expression compared to low-expression tissues, stained by IHC, Masson, and Sirius Red stains. J Scatter plots of ULBP2 expression versus collagen deposition in the human gastric TMAs. Data are expressed as mean ± SEM (***p < 0.001).
