Fig. 1: Deep scRNA-seq analyses of CD8+ T-cells from treatment-naïve NSCLC patients. | Cell Death & Disease

Fig. 1: Deep scRNA-seq analyses of CD8+ T-cells from treatment-naïve NSCLC patients.

From: The transcription factor ZEB2 mediates the antitumor efficacy of tumor-infiltrating lymphocytes in non–small cell lung cancer

Fig. 1: Deep scRNA-seq analyses of CD8+ T-cells from treatment-naïve NSCLC patients.

a t-SNE projection of CD8+ cells from the 14 treatment-naïve NSCLC patients. Each dot represents one single cell and is color-coded by tissue type. b t-SNE projection of CD8+ cells from the 14 treatment-naïve NSCLC patients displaying the nine main CD8+ clusters. Each dot represents one single cell and is color-coded by cell cluster. c Expression heatmap of the signature genes for the nine main CD8+ clusters. d Expression heatmap of key T-cell marker genes across the nine main CD8+ clusters. e t-SNE projection of CD8+ cells from the 14 treatment-naïve NSCLC patients displaying the nine main CD8+ clusters analyzed by tissue type. Each dot represents one single cell and is color-coded by cell cluster. f Tissue preference for the nine main CD8+ clusters. Each chart displays one cell cluster and is color-coded by tissue type (bars) and patient (dots). The ratio of observed cell numbers:random expectation (RO/E) was used for adjusting cell-sampling biases. RO/E > 1 shows enrichment. P-values are displayed [one-way ANOVA].

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