Fig. 3: Expression and methylation levels of positive meQTL related genes and CpG sites in LUAD tumor tissues and adjacent non-tumor tissues. | Cell Death & Disease

Fig. 3: Expression and methylation levels of positive meQTL related genes and CpG sites in LUAD tumor tissues and adjacent non-tumor tissues.

From: Integrated genetic and epigenetic analysis identifies that rs939408 affects non-smoking lung adenocarcinoma risk by modulating the DNA methylation of LRRC2

Fig. 3: Expression and methylation levels of positive meQTL related genes and CpG sites in LUAD tumor tissues and adjacent non-tumor tissues.

A LRRC2 mRNA expression in the TCGA LUAD database (510 tumor tissues and 58 adjacent non-tumor tissues). B LRRC2 mRNA expression in the GSE140343 dataset (49 tumor tissues and 49 adjacent non-tumor tissues). C LRRC2 mRNA expression in the GSE31210 dataset (226 tumor tissues and 58 adjacent non-tumor tissues). D Comparison of LRRC2 mRNA expression between LUAD tumor tissues and adjacent non-tumor tissues in in-house samples (10 tumor tissues and 10 adjacent non-tumor tissues). E SLC1A4 mRNA expression in the TCGA LUAD database. F SLC1A4 mRNA expression in the GSE31210 dataset. G Comparison of SLC1A4 mRNA expression between LUAD tumor tissues and adjacent non-tumor tissues in in-house samples. H Methylation level of cg09596674 in LUAD tumor tissues and adjacent non-tumor tissues in the TCGA dataset (455 tumor tissues and 32 adjacent non-tumor tissues). I Methylation level of cg09596674 in in-house LUAD samples (9 tumor tissues and 10 adjacent non-tumor tissues). J Methylation level of cg19220282 in LUAD tumor tissues and adjacent non-tumor tissues in the TCGA dataset. K Methylation level of cg19220282 in in-house LUAD samples. L Correlation between cg09596674 methylation and LRRC2 gene expression levels. M Correlation between cg19220282 methylation and SLC1A4 gene expression levels. LUAD lung adenocarcinoma. Significance levels: *P < 0.05, **P < 0.01, ***P < 0.001.

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