Table 1 Synergy score of LZX-2-73 combination with several chemotherapeutic agents.
Cancer cell line | Synergy score between LZX-2-73 and chemotherapeutic agents | |||||
|---|---|---|---|---|---|---|
SN38 | Oxaliplatin | Gemcitabine | Paclitaxel | 5-FU | Sorafenib | |
MIAPaCa-2 | 24.5 | 4.1 | 10.8 | 19.6 | −0.3 | 23.2 |
PDAC056T | 4.8 | 1.0 | −1.9 | −4.0 | 3.4 | 12.2 |
PDAC079T | 4.8 | −1.5 | 1.3 | 4.0 | 1.5 | 8.4 |
PDAC088T | 5.0 | 0.7 | −5.8 | −2.9 | 3.0 | 16.2 |
PDAC018T | 16.5 | −2.8 | 4.1 | −3.0 | 3.6 | 10.8 |
PC-3 | −1.4 | −4.1 | 0 | −10.5 | 6.5 | 16.8 |
HT-29 | 24.2 | −1.7 | 3.2 | 16.9 | −4.9 | 17.6 |
H358 | 19.7 | −0.3 | 1.8 | 14.3 | 5.3 | 18.6 |
H1299 | 14.4 | −4.2 | 13.9 | 20.4 | −1.9 | 22.3 |
MCF-7 | 33.6 | 2.4 | 10.8 | 6.2 | 16.8 | 42.1 |
MDA-MB-231 | 17.3 | 5.9 | 4.6 | 15.3 | 4.0 | 19.0 |
Jurkat | 2.4 | −2.2 | −5.2 | −3.7 | 0.8 | 11.4 |
Daudi | 1.0 | −10.7 | −1.6 | −2.4 | −5.4 | −4.7 |
U87 | 8.8 | −2.5 | 1.0 | 7.0 | −6.6 | 14.7 |
HepG2 | 8.4 | 3.5 | 4.1 | 6.2 | 6.0 | 17.3 |
Hep3B | 20.2 | 0.3 | 4.9 | 23.7 | 4.3 | 13.9 |
