Fig. 1: The subcellular localization and structural domains of NSUN proteins.
From: NSUNs-driven dysregulation: the next frontier in targeted cancer therapy?
A Timeline of NSUNs family in RNA m⁵C modification research. This timeline outlines key milestones in research on NSUNs-mediated 5-methylcytosine (m⁵C) modification of RNA, spanning from the first identification of m⁵C in DNA (1950) to the successive characterization of NSUN1–7 in m⁵C modification of diverse RNAs (e.g., tRNA, rRNA, mRNA) [7, 10, 11, 15, 21, 41, 44, 46, 49,50,51, 54]. B The different cellular localizations of NSUN proteins and identified their substrates. Among them, NSUN1, NSUN2, and NSUN5 are mainly located in the nucleus, NSUN3 and NSUN4 are primarily found in mitochondria, and NSUN6 is mainly located in the cytoplasm [37, 39, 43, 46, 48, 50,51,52, 54]. C The key methylation domains and active sites of NSUN proteins. These have separately displayed the methylation domains of different NSUNs based on the SMART database (https://smart.embl.de/), while marking the active sites of each NSUN protein in pink.
