Table 2 The specific mechanism by which NSUNs regulate RNA metabolism.
From: NSUNs-driven dysregulation: the next frontier in targeted cancer therapy?
Writer | Target RNA | m5C Site | Mechanism | References |
|---|---|---|---|---|
NSUN1 | 90 s pre-rRNA | 5′ETS | RNA Splicing and Processing | [41] |
NSUN2 | TIAM2 | RNA stability | [86] | |
lncRNA NKILA | RNA stability | [91] | ||
RNF115 | 3’UTR | Translation Regulation | [101] | |
RABL6, TK1 | RABL6 (5′UTR), TK1 (3′UTR) | RNA Splicing and Processing | [97] | |
PTEN | RNA Splicing and Processing | [99] | ||
ATX | C2756 (3′UTR) | RNA Localization | [105] | |
LINC01082 | RNA stability | [92] | ||
lncRNA H19 | C986 | RNA stability | [58] | |
LINC00324 | C1455 | RNA stability | [93] | |
lncRNA NR_033928 | C154 | RNA stability | [96] | |
lncRNA MALAT1 | RNA stability | [95] | ||
lncRNA SNHG15 | RNA stability | [94] | ||
lncRNA NMR | Competitively inhibit the methylation of mRNA | [59] | ||
NSUN4 | NXPH4 | C1114, C1357 | RNautophagy | [107] |
CDC42 | 3′UTR | RNA stability | [87] | |
NSUN5 | ACC1 | RNA Localization | [85] | |
28S rRNA | C3782 | Translation Regulation | [102] | |
NSUN6 | tRNA | Translation Regulation | [104] | |
EEF1A2 | RNA stability | [63] |
