Table 3 The correlation analysis between NSUNs gene expression data and drug sensitivity information.

From: NSUNs-driven dysregulation: the next frontier in targeted cancer therapy?

Gene	Drug	Correlation	P value	Gene	Drug	Correlation	P value
NSUN1	Cladribine	0.4075	0.0012	NSUN5	Thiotepa	0.3192	0.0129
NSUN1	5-Fluoro deoxy uridine 10mer	0.3787	0.0028	NSUN5	IDOXURIDINE	0.3181	0.0132
NSUN1	Cytarabine	0.3637	0.0043	NSUN5	Clofarabine	0.3162	0.0138
NSUN1	Cisplatin	0.3371	0.0084	NSUN5	Cytarabine	0.3124	0.0151
NSUN1	Gemcitabine	0.3324	0.0095	NSUN5	Gemcitabine	0.3090	0.0163
NSUN1	Clofarabine	0.3265	0.0109	NSUN5	Mocetinostat	0.3035	0.0184
NSUN1	LY-2606368	0.3213	0.0123	NSUN5	Fludarabine	0.3025	0.0188
NSUN1	Cpd-401	0.3204	0.0126	NSUN5	Belinostat	0.2972	0.0211
NSUN1	Carboplatin	0.3132	0.0148	NSUN5	ciclosporin	0.2952	0.0220
NSUN1	Raltitrexed	0.3100	0.0159	NSUN5	Karenitecin	0.2930	0.0231
NSUN1	Fludarabine	0.2989	0.0204	NSUN5	MONENSIN SODIUM	0.2912	0.0240
NSUN1	Thiotepa	0.2963	0.0215	NSUN5	CAMPTOTHECIN	0.2847	0.0275
NSUN1	Ancitabine hydrochloride	0.2939	0.0226	NSUN5	Pralatrexate	0.2825	0.0287
NSUN1	Enzalutamide	0.2918	0.0237	NSUN5	Pracinostat	0.2808	0.0298
NSUN1	TRIMETREXATE GLUCURONATE	0.2891	0.0251	NSUN5	Asparaginase	0.2749	0.0335
NSUN1	Nelarabine	0.2888	0.0252	NSUN5	Nitrogen mustard	0.2719	0.0356
NSUN1	METHOTREXATE	0.2887	0.0253	NSUN5	Fulvestrant	0.2714	0.0360
NSUN1	Karenitecin	0.2873	0.0260	NSUN5	Carboplatin	0.2705	0.0366
NSUN1	malacid	0.2871	0.0261	NSUN5	LMP776	0.2692	0.0376
NSUN1	Triapine	0.2812	0.0296	NSUN5	8-Chloro-adenosine	0.2676	0.0387
NSUN1	Methylprednisolone	0.2809	0.0297	NSUN5	XL-147	0.2635	0.0419
NSUN1	Zalcitabine	0.2775	0.0318	NSUN5	Tipifarnib	0.2625	0.0427
NSUN1	ANCITABINE HYDROCHLORIDE	0.2727	0.0350	NSUN5	Ancitabine hydrochloride	0.2584	0.0462
NSUN1	VE-821	0.2688	0.0379	NSUN5	tfdu	0.2582	0.0464
NSUN1	Pemetrexed	0.2657	0.0402	NSUN5	DMAPT	0.2564	0.0480
NSUN1	Triethylenemelamine	0.2626	0.0426	NSUN5	5-Fluoro deoxy uridine 10mer	0.2559	0.0484
NSUN1	Chlorambucil	0.2609	0.0440	NSUN5	Imexon	0.2552	0.0491
NSUN1	DIGOXIN	0.2596	0.0452	NSUN5	Dovitinib	−0.2547	0.0495
NSUN1	Floxuridine	0.2579	0.0467	NSUN5	Rebimastat	−0.3075	0.0169
NSUN1	Asparaginase	0.2553	0.0489	NSUN5	Pluripotin	−0.3104	0.0158
NSUN1	Pipobroman	0.2546	0.0496	NSUN5	JNJ−42756493	−0.3210	0.0124
NSUN1	EMD-534085	−0.2644	0.0412	NSUN5	Staurosporine	−0.3370	0.0085
NSUN1	Paclitaxel	−0.2727	0.0350	NSUN5	AT-9283	−0.3825	0.0026
NSUN1	VINORELBINE	−0.2782	0.0314	NSUN5	Dasatinib	−0.3912	0.0020
NSUN1	Vinorelbine	−0.2828	0.0285	NSUN5	BLU-667	−0.4308	0.0006
NSUN1	Kahalide F	−0.2991	0.0203	NSUN6	Nelarabine	0.5371	0.0000
NSUN1	TAK-901	−0.3015	0.0192	NSUN6	Methylprednisolone	0.4901	0.0000
NSUN1	PKI-587	−0.3135	0.0147	NSUN6	Ribavirin	0.4808	0.0001
NSUN1	ICG-001	−0.3623	0.0044	NSUN6	Zalcitabine	0.4725	0.0001
NSUN2	malacid	0.3846	0.0024	NSUN6	IDOXURIDINE	0.4493	0.0003
NSUN2	Ribavirin	0.3714	0.0035	NSUN6	Chelerythrine	0.4374	0.0005
NSUN2	Methylprednisolone	0.3573	0.0051	NSUN6	ZM-336372	0.4163	0.0009
NSUN2	Econazole Nitrate	0.3092	0.0162	NSUN6	DMAPT	0.4081	0.0012
NSUN2	Dexamethasone Decadron	0.3028	0.0187	NSUN6	6-THIOGUANINE	0.3704	0.0036
NSUN2	Clofarabine	0.3026	0.0188	NSUN6	Crizotinib	0.3585	0.0049
NSUN2	ZM-336372	0.2953	0.0220	NSUN6	ST-3595	0.3531	0.0056
NSUN2	Allopurinol	0.2926	0.0233	NSUN6	PX-316	0.3523	0.0058
NSUN2	Fludarabine	0.2887	0.0253	NSUN6	6-Thioguanine	0.3479	0.0064
NSUN2	Pyrazoloacridine	0.2653	0.0405	NSUN6	Palbociclib	0.3457	0.0068
NSUN2	Cladribine	0.2571	0.0474	NSUN6	Ergosterol	0.3452	0.0069
NSUN2	Ruxolitinib	−0.2581	0.0465	NSUN6	Econazole nitrate	0.3416	0.0076
NSUN2	Nelfinavir	−0.2733	0.0346	NSUN6	PYRAZOLOACRIDINE	0.3405	0.0078
NSUN2	Denileukin Diftitox Ontak	−0.3050	0.0178	NSUN6	3-Bromopyruvate (acid)	0.3366	0.0085
NSUN2	Dovitinib	−0.3194	0.0129	NSUN6	8-Chloro-adenosine	0.3354	0.0088
NSUN2	Alectinib	−0.3239	0.0116	NSUN6	Cyclophosphamide	0.3332	0.0093
NSUN2	NMS-E628	−0.3567	0.0051	NSUN6	Pyrazoloacridine	0.3301	0.0100
NSUN2	PF-06463922	−0.3691	0.0037	NSUN6	Obatoclax	0.3208	0.0125
NSUN3	MONENSIN SODIUM	0.3637	0.0043	NSUN6	FENRETINIDE	0.3184	0.0132
NSUN3	ZM-336372	0.3588	0.0049	NSUN6	Navitoclax	0.3103	0.0158
NSUN3	Methylprednisolone	0.3372	0.0084	NSUN6	Imexon	0.3101	0.0159
NSUN3	SB-590885	0.3041	0.0182	NSUN6	ABL-001	0.3035	0.0184
NSUN3	Vorinostat	0.3029	0.0186	NSUN6	Fostamatinib	0.2981	0.0207
NSUN3	Econazole Nitrate	0.3006	0.0196	NSUN6	Ponatinib	0.2961	0.0216
NSUN3	Haloperidol	0.2999	0.0199	NSUN6	Dexrazoxane	0.2932	0.0230
NSUN3	Pracinostat	0.2959	0.0217	NSUN6	Oxaliplatin	0.2916	0.0238
NSUN3	AT-13387	0.2949	0.0222	NSUN6	AMG-900	0.2899	0.0246
NSUN3	LEE-011	0.2786	0.0311	NSUN6	Nilotinib	0.2899	0.0246
NSUN3	GW-5074	0.2766	0.0324	NSUN6	DACARBAZINE	0.2868	0.0263
NSUN3	SNS-314	0.2754	0.0332	NSUN6	Asparaginase	0.2857	0.0269
NSUN3	Nelarabine	0.2680	0.0384	NSUN6	AMONAFIDE	0.2854	0.0271
NSUN3	Abexinostat	0.2673	0.0389	NSUN6	Vorinostat	0.2846	0.0275
NSUN3	Fenretinide	0.2571	0.0474	NSUN6	ABT-737	0.2828	0.0286
NSUN3	ANCITABINE HYDROCHLORIDE	0.2564	0.0480	NSUN6	Ifosfamide	0.2806	0.0299
NSUN3	Zoledronate	−0.2574	0.0471	NSUN6	Dexamethasone Decadron	0.2765	0.0324
NSUN3	Dasatinib	−0.2838	0.0280	NSUN6	BP-1-102	0.2746	0.0337
NSUN3	Erlotinib	−0.2841	0.0278	NSUN6	malacid	0.2738	0.0343
NSUN3	JNJ-42756493	−0.3085	0.0165	NSUN6	Fluphenazine	0.2724	0.0352
NSUN4	Vorinostat	0.4253	0.0007	NSUN6	Tivozanib	0.2710	0.0362
NSUN4	Imexon	0.4036	0.0014	NSUN6	Imatinib	0.2704	0.0366
NSUN4	Parthenolide	0.3994	0.0016	NSUN6	TAE-684	0.2653	0.0405
NSUN4	ARTENIMOL	0.3846	0.0024	NSUN6	BX-912	0.2641	0.0415
NSUN4	DMAPT	0.3725	0.0034	NSUN6	Volasertib	0.2629	0.0424
NSUN4	Cyclophosphamide	0.3689	0.0037	NSUN6	Barasertib	0.2620	0.0431
NSUN4	Artesunate	0.3675	0.0039	NSUN6	CUDC-305	0.2578	0.0468
NSUN4	Chelerythrine	0.3675	0.0039	NSUN6	1,9-Pyrazoleanthrone	0.2576	0.0469
NSUN4	Mocetinostat	0.3526	0.0057	NSUN6	Fludarabine	0.2570	0.0474
NSUN4	8-Chloro-adenosine	0.3523	0.0058	NSUN6	pentamidine isethionate	−0.2666	0.0395
NSUN4	Masoprocol	0.3406	0.0078	NSUN6	Irofulven	−0.2793	0.0307
NSUN4	Artemether	0.3367	0.0085	NSUN6	Copanlisib	−0.2899	0.0247
NSUN4	Cladribine	0.3331	0.0093	NSUN6	Deforolimius	−0.2952	0.0220
NSUN4	Cpd-401	0.3216	0.0122	NSUN6	CH-5132799	−0.3076	0.0168
NSUN4	3-Bromopyruvate (acid)	0.3170	0.0136	NSUN6	PF-04691502	−0.3116	0.0154
NSUN4	Megestrol acetate	0.3073	0.0169	NSUN6	Everolimus	−0.3493	0.0062
NSUN4	Carmustine	0.3023	0.0189	NSUN6	Pictilisib	−0.3538	0.0056
NSUN4	auranofin	0.2999	0.0199	NSUN6	AZD-8055	−0.3655	0.0041
NSUN4	Methylprednisolone	0.2983	0.0206	NSUN6	Apitolisib	−0.4068	0.0013
NSUN4	DACARBAZINE	0.2950	0.0221	NSUN6	GSK-2126458	−0.5280	0.0000
NSUN4	Nelarabine	0.2904	0.0244	NSUN7	Acetalax	0.4537	0.0003
NSUN4	HYPOTHEMYCIN	0.2902	0.0245	NSUN7	Bisacodyl, active ingredient of Viraplex	0.4469	0.0003
NSUN4	Amuvatinib	0.2859	0.0268	NSUN7	LOXO-101	0.3529	0.0057
NSUN4	Lomustine	0.2772	0.0320	NSUN7	Linsitinib	0.2614	0.0437
NSUN4	Fluphenazine	0.2665	0.0396	NSUN7	SR16157	0.2583	0.0463
NSUN4	Fostamatinib	0.2617	0.0434	NSUN7	Ribavirin	0.2548	0.0494
NSUN4	6-THIOGUANINE	0.2612	0.0438	NSUN7	Etoposide	−0.2558	0.0486
NSUN4	Fludarabine	0.2583	0.0463	NSUN7	Carboplatin	−0.2583	0.0463
NSUN4	Asparaginase	0.2583	0.0463	NSUN7	Pazopanib	−0.2618	0.0433
NSUN4	Econazole nitrate	0.2548	0.0494	NSUN7	BP-1-102	−0.2622	0.0430
NSUN4	ICG-001	−0.2668	0.0393	NSUN7	Cisplatin	−0.2637	0.0418
NSUN4	Dasatinib	−0.2906	0.0243	NSUN7	pralatrexate	−0.2639	0.0416
NSUN4	PKI-587	−0.3026	0.0188	NSUN7	Teniposide	−0.2670	0.0392
NSUN4	Kahalide F	−0.3564	0.0052	NSUN7	Lomustine	−0.2681	0.0384
NSUN5	Vorinostat	0.5133	0.0000	NSUN7	MITOXANTRONE	−0.2684	0.0381
NSUN5	Hydroxyurea	0.4642	0.0002	NSUN7	ARSENIC TRIOXIDE	−0.2689	0.0377
NSUN5	Cladribine	0.4221	0.0008	NSUN7	Estramustine	−0.2748	0.0336
NSUN5	Amuvatinib	0.3995	0.0016	NSUN7	Midostaurin	−0.2810	0.0297
NSUN5	Ergosterol	0.3926	0.0019	NSUN7	ONX-0914	−0.2812	0.0295
NSUN5	Dromostanolone Propionate	0.3862	0.0023	NSUN7	Depsipeptide	−0.2828	0.0286
NSUN5	Cpd-401	0.3765	0.0030	NSUN7	Pipamperone	−0.2856	0.0270
NSUN5	ZM-336372	0.3759	0.0031	NSUN7	Encorafenib	−0.2925	0.0233
NSUN5	JZL-195	0.3612	0.0046	NSUN7	Vincristine	−0.2973	0.0211
NSUN5	Pipobroman	0.3589	0.0049	NSUN7	DACARBAZINE	−0.3008	0.0195
NSUN5	Artemether	0.3588	0.0049	NSUN7	BLU-285	−0.3044	0.0181
NSUN5	Entinostat	0.3587	0.0049	NSUN7	Epirubicin	−0.3086	0.0164
NSUN5	Cyclophosphamide	0.3537	0.0056	NSUN7	auranofin	−0.3136	0.0147
NSUN5	LMP-400	0.3412	0.0076	NSUN7	Homoharringtonine	−0.3158	0.0140
NSUN5	Uracil mustard	0.3371	0.0084	NSUN7	Doxorubicin	−0.3210	0.0124
NSUN5	Abexinostat	0.3367	0.0085	NSUN7	COLCHICINE	−0.3228	0.0119
NSUN5	Chlorambucil	0.3340	0.0091	NSUN7	BN-2629	−0.3302	0.0100
NSUN5	Enzalutamide	0.3335	0.0092	NSUN7	Voreloxin	−0.3339	0.0091
NSUN5	Triethylenemelamine	0.3316	0.0097	NSUN7	ABT-199	−0.3401	0.0078
NSUN5	Nelarabine	0.3309	0.0098	NSUN7	Ixazomib	−0.3422	0.0074
NSUN5	Methylprednisolone	0.3293	0.0102	NSUN7	Arsenic trioxide	−0.3461	0.0068
NSUN5	Masoprocol	0.3283	0.0104	NSUN7	RAF-265	−0.3551	0.0054
NSUN5	TESTOLACTONE	0.3243	0.0115	NSUN7	Okadaic acid	−0.3598	0.0047
NSUN5	Iniparib	0.3241	0.0115	NSUN7	Ezatiostat	−0.3768	0.0030
NSUN5	Megestrol acetate	0.3241	0.0115	NSUN7	Bortezomib	−0.3796	0.0028
NSUN5	Chelerythrine	0.3228	0.0119	NSUN7	Ixazomib citrate	−0.3807	0.0027
NSUN5	Zalcitabine	0.3213	0.0123	NSUN7	Carmustine	−0.3960	0.0017

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Table 3 The correlation analysis between NSUNs gene expression data and drug sensitivity information.

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