Fig. 2: Transcriptomic features of tumor cells in TLS+HNSCC patients. | Cell Death & Disease

Fig. 2: Transcriptomic features of tumor cells in TLS+HNSCC patients.

From: CCL20 secreted by KRT15high tumor Cells promotes tertiary lymphoid structure formation and enhances anti-PD-1 therapy response in HPV+HNSCC

Fig. 2: Transcriptomic features of tumor cells in TLS+HNSCC patients.

A Clustering analysis of HNSCC, dividing them into five groups (left), and HPV infection status of the patients (right). B Functional enrichment analysis of characteristic genes in HNSCC across different groups. C Mature TLS prediction score across different groups. D Survival analysis of patients from different groups. E Heatmap analysis of highly expressed characteristic genes in distinct groups. F Correlation analysis between the highly expressed genes in Group 4, immune cell infiltration, and mature TLS prediction score. G UMAP of the tumor microenvironment landscape in HNSCC. H Spatial distribution of KRT15 expression in HPV+ and HPV−HNSCC microenvironments with scRNA-seq data. I Prognostic correlation analysis of KRT15 in HPV+ and HPV−HNSCC. *P < 0.05; **P < 0.01; ****P < 0.0001.

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