Fig. 3: Progressive retinal dystrophy in Gm20541SKO mice. | Cell Death & Disease

Fig. 3: Progressive retinal dystrophy in Gm20541SKO mice.

From: Unveiling ZNF124 as a novel determinant in neurodegeneration: orchestration of photoreceptor homeostasis through MSX2 transcriptional regulation

Fig. 3: Progressive retinal dystrophy in Gm20541SKO mice.

H&E staining of paraffin sections of the Gm20541SKO and corresponding Gm20541f/f control retinas at the ages of 8 (A), 12 (B), and 21 months (C). Scar bar: 100 μm. The lower panels show high-magnification images of the boxed areas. Scale bars: 25 μm. Quantification analysis of the ONL, INL and OS thickness of the Gm20541f/f (n = 7 from 3 mice) and Gm20541SKO (n = 6 from 3 mice) retinas from mice at the ages of 8 (D), 12 (E), and 21 months (F). OS, outer segment; IS, inner segment; ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer. *P < 0.05; **P < 0.01; ***P < 0.001. ns, no significance. The data are represented as means ± SEM.

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