Fig. 4: TTLL12-201 knockdown induces chaperone-mediated autophagy (CMA) in OE19 and OE33 cells. | Cell Death & Disease

Fig. 4: TTLL12-201 knockdown induces chaperone-mediated autophagy (CMA) in OE19 and OE33 cells.

From: Identification of isoform switching events linked with esophageal adenocarcinoma patient survival informs novel prognostic and therapeutic targets

Fig. 4: TTLL12-201 knockdown induces chaperone-mediated autophagy (CMA) in OE19 and OE33 cells.

Immunoblot of CMA markers, LAMP2A, and HSC70, in A OE19 and B OE33 EAC cell lines. Immunoblot of CHK1 and TP53 in C OE19 and D OE33 cells following TTLL12-201 siRNA knockdown alone or in combination with chemotherapy agent treatment. E Viability results and representative fluorescent images (48 h) of OE19 cells treated with APR-246. Immunoblot of CMA markers, CHK1, and TP53 in F OE19 and G OE33 cells following APR-246 treatment. NTC non-targeting control, Scale bar, 200 μm; ***, P < 0.001.

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