Fig. 6: HM13-201 knockdown induces unfolded protein response (UPR) in EAC cell lines and increases response to avelumab, an anti-PD-L1 agent. | Cell Death & Disease

Fig. 6: HM13-201 knockdown induces unfolded protein response (UPR) in EAC cell lines and increases response to avelumab, an anti-PD-L1 agent.

From: Identification of isoform switching events linked with esophageal adenocarcinoma patient survival informs novel prognostic and therapeutic targets

Fig. 6: HM13-201 knockdown induces unfolded protein response (UPR) in EAC cell lines and increases response to avelumab, an anti-PD-L1 agent.

Immunoblot of key UPR proteins in A OE19 and B OE33 cells. C HM13-201 knockdown increases response to avelumab in OE33 cells (n = 3/group). Error bars represent the standard error of the mean. SUnSET assay of D OE19 and E OE33 cells showing inhibition of protein translation. NTC non-targeting control, ND not detected, CL cleaved protein, ns non-significant, *, P < 0.05; ***, P < 0.001.

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