Fig. 3: The molecular mechanism of ferroptosis in PCa.
From: Mechanisms of ferroptosis and targeted therapeutic approaches in urological malignancies
In PCa, ferroptosis can be regulated through mechanisms involving GSH, lipid metabolism, iron metabolism, the ROS signaling pathway, and the mTOR signaling pathway. Abbreviations: PUFAs, polyunsaturated fatty acids; CoA, coenzyme A; PL-PUFAs, phospholipid-containing PUFAs; ACSL4, acyl-CoA synthetase long-chain family member 4; LPCAT3, lysophosphatidylcholine acyltransferase 3; TF, transferrin; TFR1, transferrin receptor 1; STEAP3, iron oxide reductase steam 3; DMT1, divalent metal transporter 1; NCOA4, nuclear receptor coactivator 4; LIP, labile iron pool; SLC7A11, solute carrier family 7 member 11; SLC3A2, solute carrier family 3 member 2; GSH, glutathione; GSSG, Oxidized glutathione; GPX4, glutathione peroxidase 4; NRF2, nuclear factor erythroid 2-related factor 2; ROS, Reactive Oxygen Species; SGK2, serum/glucocorticoid regulated kinase 2; CEMIP, cell migration-inducing protein; HnRNP L, heterogeneous nuclear ribonucleoprotein L; PHGDH, phosphoglycerate dehydrogenase; PPI, Polyphyllin I; TFEB, transcription factor EB; AOC1, amine oxidase copper-containing 1.
