Fig. 2: Somatic mutation and enhancer reprogramming.
From: Enhancer reprogramming: critical roles in cancer and promising therapeutic strategies
A Chromosomal structural variation leads to the repositioning of distal enhancers to target promoters. B Non-coding copy-number variation leads to enhancer function amplification. C Mutated TFs cause enhancer reprogramming. D Random mutation, pioneer action, and viral infection can create de novo enhancers.
