Fig. 5: Enhancer reprogramming and TME.
From: Enhancer reprogramming: critical roles in cancer and promising therapeutic strategies
Different cells in the tumor microenvironment respond to various signals (such as cytokines, intercellular receptor-ligand interactions, metabolites, etc.) to regulate enhancer-driven transcriptional programs. These signals modulate enhancer activity, driving the reprogramming of cancer cell transcriptional programs and remodeling of the tumor microenvironment.
