Table. 2 Summary of identified CRCs in different cancer types.
From: Enhancer reprogramming: critical roles in cancer and promising therapeutic strategies
Cancer type | CRFs | Target gene | Reference |
|---|---|---|---|
T-ALL | TAL1, GATA3, RUNX1 | MYB, TRIB2 | |
Chronic lymphocytic leukemia | PAX5, ETV6, IRF2 | BCL2, CXCR4, CD83 | [373] |
Acute myeloid leukemia with KMT2A (MLL) | MEF2D, IRF8 | MYC, HOXA9, BCL2 | [374] |
B-cell precursor acute lymphoblastic leukemia | MEF2D-fusion, SREBF1, FOS, EGR1, BCL6 | Genes related to pre-BCR signal | [375] |
Multiple myeloma | IRF4, MYC, IKZF1, RUNX1, ETS, AP-1 | - | [376] |
Esophageal cancer | TP63, SOX2, KLF5 | ALDH3A1, EGFR, BRD4 | [203] |
ELF3, KLF5, GATA6, EHF | LIF, LIFR, HNF4A, PPARG | ||
MYC, JUNB, FOSL1 | - | ||
Lung cancer | ELF3, EHF, TGIF1 | - | [383] |
E2F2, B-MYB, FOXM1 | E2F2 | [384] | |
FOSL2, FOXA2, FOXA1, JUND, ATF3 | - | [385] | |
NKX2-1, SOX1 | - | [386] | |
Squamous cancer | SREBF1, TP63, KLF5 | Genes related to lipid metabolism and methionine metabolism | |
Glioblastoma | SOX2, KLF4, EGR1, NOTCH1 | NOTCH family | [387] |
Medulloblastomas | WNT (LEF1, MAF, RUNX2, EMX2); SHH(OTX1BARHL2,MAFF,GLI2); Group3(OTX2, NRL, CRX); Group4(LMX1A, LHX2, EOMES) | CCND2, BCL2 | |
Rhabdomyosarcoma | PAX3-FOXO1 | KDM4B | [391] |
SOX8 | MYOD, MYOG | [392] | |
Neuroblastoma | PHOX2B, HAND2, GATA3 | - | [393] |
AP-1 | - | ||
TBX2 | MYCN/FOXM1 | [394] | |
ASCL1, LMO1, MYCN, HAND2, ISL1, PHOX2B, GATA3, TBX2 | ASCL1 | ||
SOX11 | SMARCC1, SMARCA4, ARID1A, HDAC2, CBX2, KDM1A, c-MYB | [204] | |
Osteosarcoma | HOXB8, FOSL1, HOXA9 | MYC, MAZ | [90] |
Gastrointestinal Stromal Tumor | FOXF1, ETV1 | KIT, ETV1 | [397] |
HAND1 | - | [398] | |
Gastric cancer | KLF5, GATA4, GATA6 | EHF | [399] |
HNF4A, ELF3, GATA4, GATA6, KLF5 | HNF1A and genes related to interleukin signal | [378] | |
Ewing sarcoma | KLF15, TCF4, NKX2-2 | EWS-FLI1 | [400] |
Pancreatic ductal adenocarcinoma | Jun, Sox2, Sox5, Twist2 | SOX2/5, Twist2, Nrf2 | [401] |
Breast cancer | BRD4, ERα | RET | [402] |
USF1, SOX4, MYBL2 | Genes related to the cell cycle, Ephrin pathway, immune processes, and oxidative phosphorylation | [403] | |
ESR1, FOXA1, FOSL2, JUND | - | [385] | |
Anaplastic large cell lymphoma | STAT3, BATF3, IRF4, IKZF1 | MYC | [404] |
Liposarcoma | FOSL2, MYC, and RUNX1 | SNAI2 | [405] |
Colorectal cancer | KLF5 | CCAT1 | [406] |
ASCL2, KLF3, MAZ, RUNX1 | - | [407] | |
Renal Cell Carcinoma | PAX8, HNF1B | Genes related to cell cycle and metabolism | [408] |
Prostate cancer | AR, FOXA1, ERG, MYC | - | [317] |
TMPRSS2–ERG, HOXB13, FOXA1 | NOTCH family | [302] | |
Embryonal tumors with multilayered rosettes | C19MC-LIN28A-MYCN | C19MC | [409] |
Liver cancer | HNF4A, FOXA2, FOXA1, CEBPB | - | [385] |
Dedifferentiated liposarcoma | FOSL2, MYC, RUNX1 | SNAI2 | [405] |
Bladder cancer | Luminal (FOXA1, GATA3, ESR1) Basal (AP-1, SMAD2/3, NF-κB, STAT3) | Genes related to inflammatory response | [410] |
