Fig. 6: CircRNA-mediated regulation of necroptosis in cardiovascular diseases (By Biorender).
From: Circular RNAs modulate cell death in cardiovascular diseases

Necroptosis is a caspase-independent cell death pathway associated with membrane rupture and inflammation. The figure depicts circRNA-regulated necroptotic signaling, including DRP1-mediated mitochondrial dysfunction and the Foxa2/RIPK3 axis, emphasizing circRNAs as emerging modulators in CVD pathogenesis.