Fig. 3: Glycerophospholipid (GPL) regulation.
From: Redox mechanism of glycerophospholipids and relevant targeted therapy in ferroptosis
ACSL4 catalyzes PUFA and acyl-CoA to form PUFA-CoA, which then forms GPL with LPL in the presence of LPAAT enzyme. GPLs is hydrolyzed by phospholipases at specific sites: PLA1 cleaves the sn-1 fatty acyl ester, PLA2 the sn-2 fatty acyl ester, PLC the phosphodiester bond between glycerol and the phosphate group, and PLD the phosphodiester bond between phosphate and the head group. PUFA polyunsaturated fatty acid, ACSL4 acyl-CoA synthesis long-chain family member, LPL lysophospholipid, LPLATs lysophospholipid acyltransferases, GPL glycerophospholipid, SFA saturated fatty acid.
