Table 1 Stereological assessment of placental tissue.

From: miR-155 suppresses angiotensin II type 1 receptor synthesis during placental morphogenesis

  

miR-155+/+

miR-155-/-

  

n = 96a

n = 86b

Volume Density

TB

0.24 ± 0.05

0.35 ± 0.03****

FC

0.51 ± 0.06

0.50 ± 0.04

MBS

0.25 ± 0.04

0.24 ± 0.02

Component Weight (g)

TB

0.02 ± 0.006

0.03 ± 0.003****

FC

0.05 ± 0.006

0.05 ± 0.004

MBS

0.02 ± 0.004

0.02 ± 0.004

Surface Density (nm2/g)

TB

2202 ± 134.8

2683 ± 71.44***

FC

4303 ± 116.7

3778 ± 53.19***

MBS

1933 ± 40.1

1857 ± 60.83

Total Surface Area (μm2)

TB

1.08 ± 0.21

1.48 ± 0.28****

FC

2.15 ± 0.37

2.08 ± 0.31

MBS

0.97 ± 0.18

1.02 ± 0.16

Mean Barrier Thickness

   

(μm)

 

115.3 ± 21.56

134.0 ± 17.94**

  1. Data are presented as mean ± SEM. Data were analyzed by Two-way ANOVA: Šídák’s multiple comparisons test. *Denotes a significant difference compared with the control (miR-155+/+) group (**≤0.005, ***≤0.0005, ****≤0.0001). Values in bold are to highlight significant changes denoted by an asterisk (*).
  2. TB trophoblasts, FC fetal capillaries, MBS maternal blood space.
  3. an = 18 litters with 4–12 fetuses and placentae each to a total of 96 (all placentae).
  4. bn = 18 litters with 1–5 fetuses and placentae each to a total of 86.
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