Table 1 Different sample sources and biopsy sites used for investigating β1-AR Expression.

From: The beta1-adrenergic receptor in the heart

Sample Sources

Biopsy site

β1-AR expression

Group

Value or ratio

References

Human

Left ventricle

Protein (fmol/mg)

Non-failing

88 ± 7.3

[25]

Failing

43.2 ± 3.41

Human

Ventricular tissue from females

Protein (fmol/mg)

Age 15.3 ± 5.5 years

86.6 ± 25.5

[22]

Age 50.8 ± 9.1 years

49.8 ± 10.3

Human

Ventricular tissue from males

Protein (fmol/mg)

Age 15.9 ± 4.7 years

75.1

[22]

Age 49.4 ± 7.5 years

58.8

Human

Left ventricle

Protein (fmol/mg)

Non-failing

73 ± 6.1

[27, 28, 182]

Failing

35 ± 6.7

Human

Right atrial appendage

mRNA

No MI

2.7

[177]

MI

4.0

Rats

Ventricular tissue

mRNA

Aged/Young

0.3

[21]

Rats

Left ventricle

Protein (fmol/mg)

4 weeks

Sham

68 ± 3.3

[142]

PO

70 ± 3.3

Sham

62 ± 3.7

VO

113 ± 9.4

24 weeks

Sham

60 ± 3.4

PO

45 ± 2.8

Sham

68 ± 4.5

VO

47 ± 3.6

Rats

Heart

mRNA (%)

Sham

1

[178]

HF

≈ 0.55

Rats

Heart

Protein (%)

Sham

1

[178]

HF

≈ 0.66

  1. This table presents the expression levels of β1-AR in the heart under different conditions. Groups were established based on heart samples, which were obtained from different anatomical regions of various species, including humans, mice and rats. The results suggested that in the context of cardiac injury, both the mRNA and protein levels of β1-AR are reduced.
  2. MI Myocardial Infarction, Sal Saline, CM Cardiomyopathy; Aged: this group consisted of 20–22-month male rats; Young: this group consisted of 3–4-month male rats, PO Pressure Overload, VO Volume, Overload, HF Heart Failures.
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