Fig. 5: Proteomic analysis of SARS-CoV-2-infected Calu-3 cells based on Tetrandrine treatment. | Cell Death Discovery

Fig. 5: Proteomic analysis of SARS-CoV-2-infected Calu-3 cells based on Tetrandrine treatment.

From: Tetrandrine-driven autophagy suppresses SARS-CoV-2 replication by modulating cholesterol and IGF signaling pathways

Fig. 5: Proteomic analysis of SARS-CoV-2-infected Calu-3 cells based on Tetrandrine treatment.The alternative text for this image may have been generated using AI.

A–D Principal Component Analysis (PCA) plots showing global proteomic distribution across experimental groups under non-infected A, B and SARS-CoV-2-infected C, D conditions. Distinct clustering patterns reveal dose-dependent effects of Tetrandrine (5 µM and 10 µM) compared with untreated (UNT) controls. In non-infected cells A, treatment with Tetrandrine induces distinct proteomic signatures. In contrast, in SARS-CoV-2-infected cells C, the separation between clusters is more prominent, indicating a pronounced impact of Tetrandrine on virus–host protein networks. Panels B and D highlight the principal proteins contributing to the variance in each condition. EVenn diagram of differentially abundant proteins (DAPs) 24 h post infection identified in SARS-CoV-2-infected cells following Tetrandrine treatment.

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