Fig. 2: SREBP1 silencing impairs proliferation and induces cell cycle arrest. | Cell Death Discovery

Fig. 2: SREBP1 silencing impairs proliferation and induces cell cycle arrest.

From: SREBP1 knockdown triggers ferroptosis by suppressing the Nrf2-XCT/GPX4 axis in ovarian cancer

Fig. 2: SREBP1 silencing impairs proliferation and induces cell cycle arrest.

A The expression of SREBP1 in ovarian cancer cells with SREBP1 silencing was detected by Western blot. B The proliferation of ovarian cancer cells with SREBP1 silencing was measured using the CCK-8 assay. C, D EdU staining and Colony formation assay were performed in ovarian cancer cells with silencing SREBP1 (Scale bar = 50 µm). E Cell cycle distribution in ovarian cancer cells with SREBP1 silencing was analyzed by flow cytometry. F The expression of cell cycle-related proteins was determined by Western blot. Data are presented as the mean ± SD of three independent experiments. p-values in panels: *p < 0.05, **p < 0.01.

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