Fig. 8: SREBP1 inhibits Keap1 transcription through direct binding to its promoter region. | Cell Death Discovery

Fig. 8: SREBP1 inhibits Keap1 transcription through direct binding to its promoter region.

From: SREBP1 knockdown triggers ferroptosis by suppressing the Nrf2-XCT/GPX4 axis in ovarian cancer

Fig. 8: SREBP1 inhibits Keap1 transcription through direct binding to its promoter region.

A SREBP1 binding site patterns predicted by the JASPAR database. B Two potential binding regions for SREBP1 on the Keap1 promoter, as predicted by the JASPAR database. C Agarose gel electrophoresis results indicate that SREBP1 exhibits chromatin-level binding affinity for two promoter regions of Keap1 in both A2780 and SKOV3 cells. D ChIP-qPCR detection results demonstrate chromatin level binding of SREBP1 to the two Keap1 promoter regions in ovarian cancer cells. Data are presented as the mean ± SD of three independent experiments. p-values in panels: *p < 0.05, **p < 0.01.

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