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Acknowledgements
The authors would like to thank Dr. Musaddeque Ahmed (Princess Margaret Cancer Centre, Canada) and Mr. Dehe Wang (Wuhan University) for helping with bioinformatics analysis, Dr. Shengzhong Duan (Shanghai Jiao Tong University) for the Adiponectin-Cre mice, Dr. Hui Yang (Institute of Neuroscience, Chinese Academy of Sciences) for the dCas9-GCN4-scFv-p65-HSF1 plasmid and the ENCODE Consortium and the ENCODE production laboratory(s) for the datasets used in the paper. This work was supported by grants from the National Natural Science Foundation of China (31570807, 31771304, 91754101, 91857000), the National Key Research and Development Program of China (2016YFA0500100, 2018YFA0800700), the 111 Project of China (B16036), the Fundamental Research Funds for the Central Universities of China (2042017kf0240, 2042017kf0187), the Key Research and Development Program of Hubei province (2019CFA067), and state key laboratory of Natural Medicines (SKLNMKF201902).
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F.H., X.L., C.C., Y.L., M.D., and Y.W. designed the study, performed experiments and wrote the paper. Y.Z., Y.L., B.-L.S., and H.H.H. contributed to data analysis and interpretation. Y.W. supervised the work and obtained the funding.
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Han, F., Liu, X., Chen, C. et al. Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice. Cell Res 30, 363–365 (2020). https://doi.org/10.1038/s41422-020-0303-z
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DOI: https://doi.org/10.1038/s41422-020-0303-z
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