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CD24Fc protects against viral pneumonia in simian immunodeficiency virus-infected Chinese rhesus monkeys

Cellular & Molecular Immunology volume 17, pages 887–888 (2020)Cite this article

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Viral pneumonia is a major cause of mortality caused by both systemic and respiratory infections. The danger-associated molecular patterns (DAMPs) released during cell death in viral infection may cause a self-propagating inflammatory response with lasting lung damage. The CD24–Siglec 10/G interaction is an emerging immune checkpoint that regulates inflammation caused by DAMPs.1,2,3 While we have demonstrated that fortifying this immune checkpoint can reduce inflammation in the colon,4 joints5 and central nervous system,6 it is unclear whether CD24Fc can protect against pneumonia. To address this issue, we evaluated the lung pathology of simian immunodeficiency virus (SIV)-infected rhesus monkeys that received either normal saline (NS) or CD24Fc.

The lung sections obtained from either necropsy or autopsy were fixed with 4% paraformaldehyde and stained with hematoxylin and eosin (H&E). The H&E-stained sections were blinded and independently scored by two researchers for viral pneumonia. The blinded scoring revealed that 5/6 (83%) of control animals developed severe pneumonia, while 2/6 (33%) of CD24Fc-treated animals developed severe pneumonia, indicating a substantial reduction in pneumonia (Table S1, Fig. 1b). The most prominent pathology finding found in both groups of monkeys was interstitial pneumonia (06031, 06047, 06329 and 07099 in the NS group; 06343 and 07029 in the CD24Fc group, Fig. 1b).

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Acknowledgements

This work was supported in part by grants from the Key Scientific and Technological Program of China (2013ZX10001002-001, 2014ZX10005-002, 2017ZX10202102-001-005), OncoImmune, Inc. and the National Natural Science Foundation of China (81601808, 81671627, U1802284).

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Authors and Affiliations

  1. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, Yunnan, China

    Ren-Rong Tian, Ming-Xu Zhang & Yong-Tang Zheng

  2. Division of Immunotherapy, Institute of Human Virology and Department of Surgery, University of Maryland Baltimore, Baltimore, MD, USA

    Mingyue Liu, Pan Zheng & Yang Liu

  3. OncoImmune Guangzhou Ltd, Guangzhou, Guangdong, China

    Xianfeng Fang

  4. OncoImmune Suzhou Ltd, Suzhou, Jiangsu, China

    Dongling Li

  5. CAS Key Laboratory for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China

    Liguo Zhang

  6. OncoImmune, Inc, Rockville, MD, USA

    Pan Zheng & Yang Liu

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  1. Ren-Rong Tian
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  2. Ming-Xu Zhang
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Correspondence to Pan Zheng, Yong-Tang Zheng or Yang Liu.

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Tian, RR., Zhang, MX., Liu, M. et al. CD24Fc protects against viral pneumonia in simian immunodeficiency virus-infected Chinese rhesus monkeys. Cell Mol Immunol 17, 887–888 (2020). https://doi.org/10.1038/s41423-020-0452-5

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